Long-term depression
| PAG Title | Long-term depression |
| PAG ID | WAG001428 |
| Type | P |
| Source Link |  KEGG |
| Publication Reference | NA |
| PAG Description | Cerebellar long-term depression (LTD), thought to be a molecular and cellular basis for cerebellar learning, is a process involving a decrease in the syptic strength between parallel fiber (PF) and Purkinje cells (PCs) induced by the conjunctive activation of PFs and climbing fiber (CF). Multiple sigl transduction pathways have been shown to be involved in this process. Activation of PFs termiting on spines in dendritic branchlets leads to glutamate release and activation of both AMPA and mGluRs. Activation of CFs, which make multiple syptic contacts on proximal dendrites, also via AMPA receptors, opens voltage-gated calcium channels (VGCCs) and causes a generalized influx of calcium. These cellular sigls, generated from two different syptic origins, trigger a cascade of events culmiting in a phosphorylation-dependent, long-term reduction in AMPA receptor sensitivity at the PF-PC sypse. This may take place either through receptor interlization and/or through receptor desensitization. |
| Species | Homo sapiens |
| Quality Metric Scores | nCoCo Score: 2,427 |
| Information Content | Rich |
| Other IDs | hsa04730 |
| Base PAG ID | WAG001428 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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